Blanchett will star in Botho Strauss play Gross und Klein, in January, while Binoche will appear in French language piece Mademoiselle Julie, in September.
Among other events will be the UK's biggest Bauhaus exhibition in 40 years.
The Barbican said its "world-class events" put it "at the heart if the London 2012 Festival".
This summer's festival is the culmination of London's Cultural Olympiad programme.
'International moment'The Bauhaus: Art as Life exhibition will include work from artists who attended the German modern art school, which was founded by Walter Gropius in 1919.
It will feature Paul Klee, Marcel Breuer, Anni Albers and Mies van der Rohe works.The Barbican programme will include theatre, art, architecture, design, film, music, opera and dance.
Barbican managing director Sir Nicholas Kenyon said there would be "something for everyone".
"In 2012 London welcomes the world for the Olympic and Paralympic Games and the Barbican will be at the forefront of that international moment with an extraordinary range of great cultural experiences for all," he added.
Other highlights will include the UK premiere, in May, of Robert Wilson and Philip Glass' 1976 work Einstein on the Beach, An Opera in Four Acts.
As part of the finale to the Barbican's London 2012 Festival celebrations, the Jazz at Lincoln Center Orchestra will return, following on from their residency last year.
They will perform with trumpeter Wynton Marsalis as well as Simon Rattle, who will conduct the Barbican's resident orchestra, the London Symphony Orchestra.
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